Does CBD Oil Cause High Cholesterol?

As one navigates the labyrinth of health, wellness, and alternative medicine, it often feels like treading a tightrope suspended over a chasm of misinformation and misconception. Among the myriad products that have attracted substantial attention recently is Cannabidiol (CBD) oil, a byproduct of the cannabis plant that is praised for its potential therapeutic properties. With increasing interest in its potential benefits, questions about possible side effects have begun to surface.

One query that has emerged relates to whether CBD oil can cause high cholesterol, an issue of significant concern given the growing prevalence of cardiovascular diseases. Cholesterol, akin to an unsung hero or villain depending on its type, plays vital roles within the body while also posing potential risks when levels are unbalanced. High cholesterol levels are associated with increased risk factors for heart disease and stroke; therefore, understanding any connection between CBD oil usage and cholesterol levels becomes crucially important.

This article strives to shed light on this matter by exploring what constitutes cholesterol, how it is diagnosed, and, most importantly, how CBD oil might influence these levels based purely on existing scientific research. The objective is not merely to add another voice to ongoing debates but to provide fact-based information to aid readers in making informed decisions regarding their health choices.


  • CBD oil may help regulate cholesterol levels in the body and improve the ratio of good cholesterol to bad cholesterol.
  • CBD oil has anti-inflammatory properties that can reduce inflammation in the arterial walls caused by high cholesterol.
  • CBD oil interacts with the body’s endocannabinoid system and can regulate blood sugar levels and overactive immune cells, potentially reducing the clotting risks associated with high cholesterol.
  • CBD oil has the potential to be used as an adjunctive treatment alongside traditional cholesterol medication.

CBD Oil and cholesterol

Emerging research suggests a potential correlation between CBD oil usage and cholesterol regulation, highlighting its prospective role in cardiovascular health management and the risk reduction of diseases like arteriosclerosis.

Studies have shown that CBD oil may have an effect on high cholesterol levels by interacting with the endocannabinoid system within our bodies, which is responsible for maintaining internal balance or homeostasis. As such, the use of CBD oil might affect how the body processes lipids, potentially aiding in managing harmful cholesterol levels and contributing to overall heart health.

Furthermore, some clinical trials suggest that regular consumption of CBD oil could lower blood cholesterol levels while improving the ratio of good (HDL) to bad (LDL) cholesterol. Such findings indicate that using CBD as an adjunctive treatment alongside traditional cholesterol medication could be beneficial in controlling high cholesterol.

However, it’s important to note that more comprehensive studies are necessary to further substantiate these claims and fully understand how CBD interacts with both blood lipid profiles and established medications for treating elevated cholesterol levels.

The Meaning and Causes of Cholesterol

Understanding the nature and causes of cholesterol requires delving into its role as a lipid molecule essential for various bodily functions.

Cholesterol is a waxy, fat-like substance that your body needs to build cells, produce certain hormones, synthesize vitamin D, and maintain cell membranes.

This lipid molecule plays an integral part in maintaining cholesterol homeostasis in the body. However, when too much of it accumulates in the bloodstream due to factors such as genetics, a lack of exercise, or an unhealthy diet rich in dietary cholesterol and saturated fats, it can lead to high cholesterol levels, which are a major risk factor for heart disease and stroke.

The process by which high cholesterol levels become harmful involves low-density lipoprotein (LDL), often referred to as ‘bad’ cholesterol.

LDL carries most of the cholesterol that’s delivered to cells throughout the body. However, when there’s too much LDL circulating in the blood stream due to poor lifestyle choices or genetic predisposition, among other causes of high cholesterol levels, it can slowly build up on the inner walls of the arteries, supplying oxygen-rich blood to your heart and brain.

These deposits, known as plaques, can reduce blood flow through these arteries over time, leading to conditions like coronary artery disease or even potentially fatal events like heart attacks or strokes, proving that while necessary for various bodily functions, managing this complex lipid molecule is crucial for overall health.

How Do You Tell If You Have High Cholesterol Levels?

Recognizing high cholesterol levels is not straightforward, as this condition often presents with no noticeable symptoms, making regular check-ups with a GP and routine blood tests crucial for maintaining a healthy cholesterol balance. Understanding the types of cholesterol and their role in body functions can help manage concentration effectively. LDL (Low-Density Lipoprotein), often labeled as bad cholesterol, carries extra cholesterol to the blood vessel walls, causing plaque buildup that leads to heart disease. High LDL levels therefore signify unhealthy cholesterol levels.

A blood test referred to as a lipid profile or lipid panel is used by doctors to measure various forms of lipids (fats) in one’s bloodstream, such as triglycerides, HDL (High-Density lipoprotein—good cholesterol), and LDL levels, which give an insight into heart health. For individuals over 45 or those with certain risk factors like smoking or diabetes, it becomes even more imperative to have these routine checks. This procedure helps detect high cholesterol levels early enough for remedial actions to be taken before any potential harm occurs.

Cholesterol Type Role
LDL Carries extra cholesterol that causes plaque buildup on blood vessel walls.
HDL Helps remove excess LDL from your bloodstream.
Triglycerides A type of fat stored in your body’s cells.

The table above provides a simple breakdown of the types of lipids measured during a routine check-up for determining one’s cholesterol concentration.

How is CBD Oil Connected to Cholesterol?

The intricate relationship between Cannabidiol (CBD) oil and cholesterol levels extends beyond the simplistic question of whether CBD oil causes high cholesterol. Further exploration reveals a multifaceted interaction, with CBD oil potentially influencing various factors that indirectly affect cholesterol levels.

These encompass the reduction of inflammation in blood vessel walls, mitigation of blood sugar levels, stress alleviation, control of high blood pressure, and suppression of appetite and weight—all critical elements in the holistic management of cholesterol.

Reducing Inflammation in the Walls of Blood Vessels

High cholesterol levels can cause inflammation in the walls of blood vessels, a condition that CBD oil potentially mitigates. It is postulated that cannabinoids, which are compounds derived from the hemp plant, have anti-inflammatory properties and can reduce inflammation in arterial walls caused by high cholesterol.

When there is an excessive accumulation of fatty deposits (cholesterol) on the inner lining of blood vessels, it triggers an immune response leading to inflammation. This inflammatory process could make blood vessels less flexible and more prone to clot formation, leading to severe medical conditions such as heart attacks or strokes.

Cannabinoids from CBD oil bind with certain receptors in the body’s endocannabinoid system, reducing inflammation. The hemp plant-derived substance may inhibit adhesion and migration of immune cells to sites of inflammation. By suppressing these responses, CBD oil could potentially help prevent plaque buildup on arterial walls.

As a result, regular use of CBD oil might be beneficial for people with high cholesterol levels as a means to mitigate related health risks. The molecular structures in CBD oil interact with our body’s own naturally occurring cannabinoid receptors within the endocannabinoid system. This interaction stimulates processes that regulate various physiological mechanisms, including pain sensation, mood regulation, sleep cycle, and, importantly, immune response.

Therefore, it is hypothesized that this interaction has the potential to control overactive immune cells, thereby reducing their contribution to the clotting risks associated with high cholesterol levels. Ultimately, further research into this fascinating area will enable us to fully understand how CBD oil influences high cholesterol levels and its subsequent effects on our vascular health.

Reducing Blood Sugar Levels

Beyond its potential anti-inflammatory effects, CBD oil has also been associated with the regulation of blood sugar levels, playing a significant role in managing cases of high cholesterol.

Recent scientific studies have shown that cannabidiol (CBD), one of the active constituents found in hemp seed oil, can influence metabolic processes in the body that control blood sugar levels.

CBD can help regulate glucose metabolism by interacting with specific receptors in the endocannabinoid system. The endocannabinoid system is a complex cell-signaling system that helps maintain homeostasis. CBD does this by interacting with specific receptors in the endocannabinoid system.

Insulin resistance is often observed as a common denominator among individuals suffering from high cholesterol and elevated blood sugar levels.

This condition results from the inability of cells to respond effectively to insulin, leading to an accumulation of glucose in the bloodstream and subsequently higher levels of cholesterol.

Interestingly, research has demonstrated promising benefits of cannabidiol (CBD) oil in managing this condition by targeting resistin, a hormone produced by fat and immune cells linked to both obesity and insulin resistance.

Through its interaction with cannabinoid receptors present on these cells, CBD may reduce resistin levels, thus improving insulin sensitivity and ultimately contributing to lower blood sugar and cholesterol levels.

Reducing Stress

Stress, a common ailment in today’s fast-paced world, can exert detrimental effects on health, including an elevation in cholesterol levels. High cholesterol is a significant risk factor for cardiovascular disease and heart attacks.

Chronic stress leads to the overproduction of adrenaline and cortisol, hormones that can spike the level of cholesterol in the body. However, recent research indicates that CBD oil may help mitigate these harmful effects by reducing stress levels.

CBD oil has been observed to activate serotonin receptors present within the central nervous system; this activation process helps moderate responses to stress stimuli. In a broader context, CBD oil’s activation of these serotonin receptors results in decreased cortisol and adrenaline secretion.

This chain reaction subsequently decreases the level of cholesterol within the bloodstream and reduces the potential risks associated with high cholesterol, such as cardiovascular disease or heart attack. Furthermore, additional benefits of using CBD oil include relief from depression and anxiety—two major conditions often linked with chronic stress—offering individuals a holistic approach toward managing their overall wellbeing while maintaining healthy cholesterol levels.

Reducing High Blood pressure

Transitioning from the discussion on stress reduction, another critical health area where CBD oil has shown potential efficacy is in managing high blood pressure, particularly in individuals with elevated cholesterol levels. This relationship between CBD oil and blood pressure arises from the compound’s ability to mediate various physiological functions, including inflammation control and arterial passage dilation.

Research studies have identified a correlation between the use of CBD oil and reduced high blood pressure. The mechanism through which this occurs is multifaceted. Firstly, CBD oil has been found to widen arterial passages by relaxing and dilating the blood vessels’ walls. This widening allows for improved blood flow, reducing the strain on the heart and subsequently lowering high blood pressure. Secondly, CBD oil possesses anti-inflammatory properties that can reduce inflammation within these arterial passages, further improving cardiovascular effects and enhancing overall heart function.

Moreover, it is important to note that individuals with high cholesterol often struggle with excess cholesterol buildup in their arteries, a condition known as atherosclerosis, which significantly contributes to increased blood pressure levels. By promoting increased high-density lipoprotein (the ‘good’ cholesterol) production while decreasing low-density lipoprotein (the ‘bad’ cholesterol), CBD oil may help maintain balanced cholesterol levels, thus mitigating some risks associated with elevated blood pressure.

In conclusion, evidence suggests that CBD oil could be beneficial in managing hypertension, especially among those with heightened cholesterol levels, thanks to its capacity to enhance both vascular and metabolic health simultaneously. However, more research is required for definitive conclusions regarding long-term use and potential side effects.

Reducing Appetite and Weight

Another compelling benefit of regular CBD use is its potential influence on weight management through mechanisms such as appetite suppression, reduced food cravings, and the promotion of white to brown fat conversion. This hemp-derived compound interacts with cannabinoid receptors in the body’s endocannabinoid system, which have been found to play key roles in regulating appetite and energy balance. CBD, a non-psychoactive component extracted from the Cannabis sativa plant, can help improve the relationship between the stomach and brain. This allows for a better understanding of hunger and satiety cues by potentially altering the activity of neurons involved in these processes.

Several studies point towards an association between regular CBD use and a lower BMI (Body Mass Index). The consumption method appears to significantly influence this association; oral administration or inhalation seem to yield more significant results compared to topical application. Furthermore, it’s suggested that CBD promotes browning of adipose tissues, converting energy-storing white fats into energy-burning brown fats, thereby aiding in reducing appetite and weight.

Study Key Findings
Russo et al. (2018) Regular CBD users had a lower BMI compared to non-users.
Penner et al. (2013) Cannabis use was associated with a smaller waist circumference.
Parray & Yun (2016) CBD promotes browning of white adipose tissues.
Di Marzo & Piscitelli (2015) Endocannabinoid levels were inversely related to abdominal obesity.

These findings highlight the potential value of incorporating CBD into weight-management strategies. While further research is needed for definitive conclusions, existing evidence suggests that regular CBD usage could be beneficial for individuals seeking support in managing their weight.


In a paradoxical twist, despite the negative connotations associated with high cholesterol levels, CBD oil does not contribute to this issue. Studies suggest it may actually have the potential to improve lipid profiles and aid in overall heart health.

In conclusion, while further research is still necessary, current findings imply that CBD oil could likely be part of a solution rather than a contributor to high cholesterol problems. This serves as an ironic counterpoint to initial apprehensions about its possible adverse effects on cholesterol levels.


No, CBD oil does not cause high cholesterol. In fact, research has shown that CBD can help lower cholesterol levels by reducing inflammation and improving the metabolism of fat. It has also been shown to improve HDL (good) cholesterol levels.

CBD has the ability to reduce inflammation in the body, which is a key factor in the development of high cholesterol. It has also been shown to improve the metabolism of fat and increase good cholesterol levels. While more research is needed in this area, CBD may be a potential treatment for high cholesterol.

CBD oil can help lower cholesterol by reducing inflammation, improving the metabolism of fat, and increasing good cholesterol levels. Additionally, CBD has been shown to have antioxidant and anti-inflammatory properties, which can help prevent the buildup of cholesterol in your arteries.

Yes, CBD oil is generally considered safe for people with high cholesterol. However, it is important to talk to your doctor before using any CBD products if you are taking any prescription medications or have any underlying medical conditions.

CBD interacts with the body’s endocannabinoid system (ECS), which plays a role in regulating inflammation. It can bind to receptors in the ECS and activate processes that reduce and regulate inflammation.

CBD capsules may be able to help lower cholesterol by reducing inflammation and improving the metabolism of fat in the body. However, it is important to talk to your doctor before using any CBD products for cholesterol treatment.

LDL cholesterol is often referred to as “bad” cholesterol, as it can contribute to the buildup of cholesterol in the arteries and increase the risk of heart disease. HDL cholesterol is often referred to as “good” cholesterol, as it helps remove excess cholesterol from the body and reduces the risk of heart disease.

Yes, high levels of LDL cholesterol in the blood increase the risk of developing heart disease and stroke. It can also lead to the buildup of atherosclerotic plaques in the arteries, which can restrict blood flow and cause a variety of health problems.

There is no one-size-fits-all answer to this question, as the amount of CBD oil you should take will depend on your individual needs and health status. It is important to start with a low dose and gradually increase it until you achieve the desired effect. It is also important to talk to your doctor before using any CBD products for cholesterol treatment.

You can buy CBD oil products online or at your local health food store. However, it is important to do your research and make sure you are buying from a reputable source. Look for products that have been third-party tested and have a certificate of analysis available.


Assa-Glazer, Tal, et al. “Cannabis extracts affected metabolic syndrome parameters in mice fed high-fat/cholesterol diet.” Cannabis and Cannabinoid Research 5.3 (2020): 202-214. [HTML]

Jadoon, Khalid A., Garry D. Tan, and Saoirse E. O’Sullivan. “A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.” JCI insight 2.12 (2017). [HTML]

Passie, Torsten, et al. “Mitigation of post‐traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence.” Drug testing and analysis 4.7-8 (2012): 649-659. [PDF]

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