CBD for Fibromyalgia

CBD for Fibromyalgia: Research, Treatment, Side Effects, and More

There’s been a lot of buzz about CBD as an alternative treatment for fibromyalgia, but it’s important to understand the current research, potential benefits, and side effects before considering this option.

As a cannabinoid derived from cannabis plants, CBD has shown promise in providing pain relief for various chronic pain conditions. Studies have suggested that it can alleviate symptoms of fibromyalgia, offering hope to patients suffering from this debilitating condition.

However, while some fibromyalgia patients report positive outcomes with hemp-derived CBD products or medicinal cannabis, others may not experience the same fibromyalgia pain relief. It’s crucial to remember that everyone reacts differently, and what works for one might not work for another.

Furthermore, like any other medication or supplement, potential side effects should be considered when weighing up your options.


  • Fibromyalgia is a chronic pain disorder with no known cure.
  • CBD has been used as an alternative treatment for chronic pain and inflammation.
  • More human studies are needed to determine the effectiveness of CBD for fibromyalgia.
  • The combination of CBD and THC may be more effective for fibromyalgia symptoms.

How does CBD work for fibromyalgia?

When it comes to chronic pain disorders, cannabinoids can interact with receptors in your body, potentially alleviating discomfort and enhancing sleep quality. For patients with fibromyalgia who experience musculoskeletal pain, neuropathic pain, and poor quality of life, CBD could be a viable treatment option.

Research on CBD for fibromyalgia

We’ll be discussing key findings from a 2019 Dutch study, which explored the effects of cannabis high in both CBD and THC on fibromyalgia patients.

You’ll also learn about an Israeli study conducted the same year in which medical cannabis was observed as a potential safe and effective treatment for this chronic pain disorder.

2019 Dutch study

In the 2019 Dutch study, it was found that a strain of cannabis high in both CBD and THC provided more relief to fibromyalgia patients than a placebo. The research focused on chronic pain disorders like fibromyalgia causing widespread pain and sleep disturbances, treatment using cannabis products, specifically ones high in both CBD and THC, interaction with cannabinoid receptors, potentially reducing pain, and improvement in sleep quality for chronic pain patients.

Patients reported significant relief from their symptoms. Interestingly, strains high only in CBD didn’t show such results, indicating that THC might also play a crucial role alongside CBD. However, this is just one study; further research is required to solidify these findings and explore potential side effects or long-term impacts.

2019 Israeli study

Shifting our focus to the 2019 Israeli study, it’s worth noting that this research found significant potential for medical cannabis as a safe and effective treatment option.

The study observed participants suffering from fibromyalgia, a chronic condition causing severe pain. Initially, they started with low doses of the therapeutic option—medical cannabis products—and gradually increased the dosage over six months.

As an alternative to traditional pharmacological treatments like pain medications, these hemp oil-based products showed promising results in enhancing health outcomes and improving sleep.

Remarkably, by the end of the study period, only 7.9% reported high levels of pain compared to 52.5% at commencement, a testament to their increased pain self-efficacy and improved quality of life.

CBD’s side effects

While CBD is generally considered safe, it’s important to note that you might still experience some side effects such as fatigue, diarrhea, appetite changes, or weight changes. These are common reactions when introducing new medicines into your body.

In human studies and observational trials with participants using CBD for various health conditions, the following potential side effects have been noted:

  • Changes in mood
  • Dry mouth
  • Lightheadedness
  • Low blood pressure

More serious but rare side effects can include cognitive dysfunction or liver injury. Remember that everyone’s response to CBD is unique, and these may not affect you at all. However, if you experience any discomfort or concerning symptoms while using CBD as an effective treatment for fibromyalgia, consult with your healthcare provider immediately.


While the FDA hasn’t officially approved it for this use, research points to its potential efficacy in managing pain and stiffness.

However, more studies are needed to fully understand its impact.

Be mindful of potential side effects and interactions with other medications or supplements.

Remember, a combination of CBD and THC could offer the most relief due to the ‘entourage effect‘.


CBD, or cannabidiol, is a natural compound found in cannabis plants. It is one of many cannabinoids, which are substances that can affect the body’s endocannabinoid system.

CBD may have potential benefits for people with fibromyalgia. Some studies suggest that CBD may help with symptom relief, pain management, and improving quality of life for those suffering from fibromyalgia.

CBD oil and hemp oil are not the same. CBD oil is derived from the flowers and leaves of hemp plants and contains higher levels of CBD. Hemp oil, on the other hand, is derived from the seeds of hemp plants and does not contain significant levels of CBD.

CBD is generally well-tolerated, but some people may experience side effects such as fatigue, diarrhea, changes in appetite, and dry mouth. It is important to start with a low dosage and gradually increase to find the optimal dosage for individual needs.

The legality of CBD use varies depending on the country and state. In many countries, CBD derived from hemp is legal, but CBD derived from marijuana may be subject to stricter regulations. It is important to research and understand the laws in your specific location.

Yes, there are various forms of CBD products available for fibromyalgia, including oils, tinctures, capsules, topicals, and edibles. Each form has its own advantages and it may be a personal preference as to which form works best for individual needs.


Berger, Amnon A., et al. “Cannabis and cannabidiol (CBD) for the treatment of fibromyalgia.” Best Practice & Research Clinical Anaesthesiology 34.3 (2020): 617-631.

van de Donk, Tine, et al. “An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia.” Pain 160.4 (2019): 860. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430597/

van de Donk, Tinea; Niesters, Mariekea; Kowal, Mikael A.b; Olofsen, Erika; Dahan, Alberta,*; van Velzen, Moniquea. An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia. PAIN 160(4):p 860-869, April 2019. | DOI: 10.1097/j.pain.0000000000001464 https://journals.lww.com/pain/fulltext/2019/04000/An_experimental_randomized_study_on_the_analgesic.11.aspx

Sagy, I.; Bar-Lev Schleider, L.; Abu-Shakra, M.; Novack, V. Safety and Efficacy of Medical Cannabis in Fibromyalgia. J. Clin. Med. 20198, 807. https://www.mdpi.com/2077-0383/8/6/807/htm

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